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July 6, 2026Biochemistry and Biophysics ReportsOpen Access

Impact of carbon and nitrogen source variation on B-vitamin accumulation in Yarrowia lipolytica: Toward microbial fortification of food ingredients

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Authors

PKPanwana KhunnonkwaoSTSitanan ThitiprasertAMAtsushi Minamino

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Overview

Randomized trial evaluates B-vitamin yields in Yarrowia lipolytica using varied nutrient sources, suggesting optimized fermentation strategies for food ingredients.

Key Points

  • The study aims to explore how different carbon and nitrogen sources affect B-vitamin accumulation in Yarrowia lipolytica.
  • Controlled fermentations using glucose, xylose, mixed sugars, and lignocellulosic sugars.
  • Evaluation of diverse nitrogen sources including yeast extract.
  • Measurement of biomass and B-vitamin yields.
  • Glucose with yeast extract led to the highest accumulation of thiamine (B1), niacin (B3), and pyridoxine (B6).
  • Mixed sugars supported maximal intracellular folate (B9) content.
  • Cobalamin (B12) was consistently retained, suggesting uptake from the medium rather than biosynthesis.

Cite This Study

Khunnonkwao et al. (2026) studied this question.

synapsesocial.com/papers/6a4b45da997070ff83b5b6dfhttps://doi.org/10.1016/j.bbrep.2026.102699
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Analysis of the Biomass Production and Nutritional Profiles of Two Wild-Type Strains of Yarrowia lipolytica2025
  2. 2Regulatory effects of carbon and nitrogen nutrition on lipid accumulation by Yarrowia lipolytica cultivated with high-concentration volatile fatty acids2025
  3. 3Production of High-Value-Added Bacterial Nanocellulose with Thinner Fiber Using Novel <i>Yarrowia lipolytica</i> Extract from Erythritol Industry Waste2024 · 4 citations
  4. 4Exploring the nutritional properties and natural biofortification of yeasts when fermenting strawberries, beetroots, onions, and others2025
  5. 5Yarrowia lipolytica as a promising cell factory for microbial production of value-added nutraceuticals2025