Key result
Inactivation of ERRα and ERRγ in cardiomyocytes led to the loss of the ventricular cardiomyocyte gene profile, establishing their essential role in maintaining ventricular identity.
Why the study?
The mechanisms responsible for chamber-selective transcriptional programs underpinning structural and functional differences between atrial and ventricular cardiomyocytes remain largely undefined.
Population
Atrial and ventricular cardiomyocytes
Comparison
Inactivation of ERRα and ERRγ vs controls in cardiomyocytes
Design
In vivo preclinical mechanistic study
Authors
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Preclinical only; leaves open ERRα/γ as chamber-specific targets pending human validation.
Identification of 229 chamber-selective enhancers and the discovery that ERRα/γ are essential for maintaining ventricular cardiomyocyte identity provides a foundational resource for understanding cardiac gene regulation and developing targeted gene therapies.
Cao et al. (2023) studied Cardiac chamber-selective transcriptional programs. Inactivation of ERRα and ERRγ was evaluated on Ventricular cardiomyocyte identity and gene profile. Inactivation of ERRα and ERRγ in cardiomyocytes led to the loss of the ventricular cardiomyocyte gene profile, establishing their essential role in maintaining ventricular identity.
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