Key result
Adverse pregnancy outcomes and poor maternal cardiometabolic health link to higher CVD risk across generations.
Why the study?
Maternal conditions influence adverse pregnancy outcomes, subsequent maternal cardiovascular disease risk factors, and offspring cardiovascular health via developmental programming.
Pregnancy serves as a cardiovascular stress test where adverse outcomes highlight the need for comprehensive primordial, primary, and secondary cardiovascular prevention strategies for both mother and child.
Pregnancy history may inform CV risk stratification; extends intergenerational links but leaves open prospective intervention trials.
Pregnancy represents a stress test for every woman's cardiovascular (CV) system, and a pre-existing maternal unfavorable cardio-metabolic phenotype can uncover both adverse pregnancy outcomes and the subsequent development of cardiovascular disease (CVD) risk factors during and after pregnancy. Moreover, the maternal cardiac and extracardiac environment can affect offspring's cardiovascular health through a complex mechanism called developmental programming, in which fetal growth can be influenced by maternal conditions. This interaction continues later in life, as adverse developmental programming, along with lifestyle risk factors and genetic predisposition, can exacerbate and accelerate the development of CV risk factors and CVD in childhood and adolescence. The aim of this narrative review is to summarize the latest evidences regarding maternal-fetal dyad and its role on primordial, primary and secondary CV prevention.
No takes yet. Share an insight, caveat, or question.
Bucciarelli et al. (2024) conducted a review in Pregnancy-related cardiovascular risk. Adverse pregnancy outcomes and maternal cardiometabolic risk factors was evaluated. Adverse pregnancy outcomes and unfavorable maternal cardiometabolic phenotypes significantly increase the short- and long-term risk of cardiovascular disease for both mothers and their offspring.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: