Key result
SAMP8 mice exhibited a significant decrease in parasympathetic nervous function and circadian rhythm loss of locomotive activity at 40 weeks of age compared to 20-week-old mice.
Why the study?
It had not been clarified whether aging affects autonomic nervous activity in SAMP8 mice, prompting this study to evaluate its utility as an animal model.
Does accelerated aging to 40 weeks alter autonomic nervous function and circadian rhythms in senescence-accelerated mouse-prone 8 (SAMP8) models?
Does accelerated aging to 40 weeks alter autonomic nervous function and circadian rhythms in senescence-accelerated mouse-prone 8 (SAMP8) models?
The SAMP8 mouse strain is a valid preclinical model for studying age-related decline in autonomic nervous function, as it demonstrates early attenuation of parasympathetic activity and circadian rhythm disruption by 40 weeks of age.
Supports SAMP8 mice as model for age-related autonomic decline; leaves open translation to human cardiovascular aging.
The senescence-accelerated mouse (SAM) strain has been established as an inbred strain with an accelerated aging phenotype. SAM prone-8 (SAMP8), one of the SAM strain, exhibits learning disability, immune deficiency, and circadian rhythm loss at a relatively young age. However, it has not been clarified whether aging affects the autonomic nervous activity in SAMP8. The aim of this study was to clarify the utility of SAMP8 in age-related studies of autonomic nervous function. Electrocardiogram (ECG), body temperature, and locomotor activity were recorded to evaluate bio-behavioral activities. Autonomic nervous activity was evaluated via power spectral analysis of heart rate variability from ECG recordings. SAMP8 significantly decreased both biological and autonomic nervous functions, and the animals exhibited circadian rhythm loss of locomotive activity at as early as 40 weeks of age compared with a control strain at the same age. We concluded that the SAMP8 strain can be used as an animal model for age-related studies of autonomic nervous function.
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Chikamoto et al. (2019) studied Aging and autonomic nervous function (n=15). Aging (40 weeks of age) vs. 20 weeks of age and SAMR1 control strain was evaluated on Autonomic nervous activity (LF and HF power from HRV) and circadian rhythm of bio-behavioral activities (p=<0.05). SAMP8 mice exhibited a significant decrease in parasympathetic nervous function and circadian rhythm loss of locomotive activity at 40 weeks of age compared to 20-week-old mice.
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