Key result
Sotalol combination therapy (with flecainide or digoxin) successfully managed two cases of sustained fetal supraventricular tachycardia complicated by severe secondary hydrops fetalis.
Why the study?
There is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis.
Does sotalol combination therapy successfully manage sustained fetal SVT complicated by severe hydrops fetalis?
Case Report (n=2)
Does sotalol combination therapy successfully manage sustained fetal SVT complicated by severe hydrops fetalis?
Sotalol combination therapy (with flecainide or digoxin) may be an effective adjunct for managing sustained fetal SVT complicated by severe hydrops fetalis.
Answers are grounded in this paper and cite their sources.
Sotalol combinations may aid refractory fetal SVT with hydrops; hypothesis-generating and requires prospective validation.
Sustained fetal supraventricular tachycardia (SVT) complicated by hydrops fetalis carries a significant risk of morbidity and mortality. While there is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis, there exists significant nonrandomized experience with a number of antiarrhythmic agents that has founded the basis for management. Furthermore, recently published meta-analyses and ongoing multicenter prospective studies have aimed to bridge the gap in the literature. We report two cases of sustained fetal SVT with severe secondary hydrops fetalis managed successfully with flecainide-sotalol combination therapy in one case and sotalol-digoxin combination therapy in the second and review the literature for the management of fetal SVT.
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Refaat et al. (2019) conducted a case report in Sustained fetal supraventricular tachycardia with severe secondary hydrops fetalis (n=2). Sotalol combination therapy (flecainide-sotalol or sotalol-digoxin) was evaluated on Successful management of fetal SVT and hydrops fetalis. Sotalol combination therapy (with flecainide or digoxin) successfully managed two cases of sustained fetal supraventricular tachycardia complicated by severe secondary hydrops fetalis.
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