Key result
Administration of H2O2 to right atrial neurons in dogs altered neuronal activity, an effect blocked by deferoxamine and cromakalim, indicating sensitivity to oxygen-derived free radicals.
Intrinsic cardiac neurons are sensitive to oxygen-derived free radicals in situ, an effect that is modulated by KATP channels.
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Hypothesis-generating for oxidative stress effects on cardiac neurons; leaves open translation to human arrhythmias or function.
Thompson et al. (1998) studied this question. H2O2, deferoxamine, and cromakalim was evaluated on Neuronal activity. Administration of H2O2 to right atrial neurons in dogs altered neuronal activity, an effect blocked by deferoxamine and cromakalim, indicating sensitivity to oxygen-derived free radicals.
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