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July 6, 2026Intestinal ResearchOpen Access

Post-treatment simplified MaRIA score predicts clinical outcome in Crohn’s disease patients

Ami Kawamoto K Takenaka Junichi Tsuchiya Momo Wakui Kazuo Ohtsuka Ryuichi Okamoto

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Key Points

This research aims to assess the predictive value of the simplified MaRIA score for clinical outcomes in patients with Crohn’s disease post-biological treatment.
Calculations of the simplified MaRIA score were performed by radiologists blinded to clinical activity.
Clinical outcomes were evaluated for events after post-treatment magnetic resonance enterography (MRE).
Cox regression analysis was employed for calculating univariable and multivariable hazard ratios.
Higher simplified MaRIA scores were associated with an increased risk of clinical relapse.
Cox regression indicated significant hazard ratios (HR) for relapse evaluated in relation to the simplified MaRIA scores.
An optimal threshold for the simplified MaRIA score was established using receiver operating characteristic curve analysis.

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Implication

Evaluates the simplified MaRIA score predicting clinical relapse in Crohn’s disease, suggesting its utility in treatment monitoring.

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Cite This Study

Kawamoto et al. (2026) studied this question.

synapsesocial.com/papers/6a4de835d2ea289ef628305d https://doi.org/10.5217/ir.2026.00077

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1P0212Tracing Transmural Healing in Crohn’s Disease with MRI: correlation between MR enterography, laboratory findings and endoscopy – a retrospective single centre cohort studyCohort Study · 2026
2Magnetic resonance imaging-based simplified MaRIA scores are associated with future surgery in Crohn’s disease, but modest correlation with ileo-colonoscopic inflammation limits their utility in clinical trials: results from the PROFILE trialCohort Study · 2026 · 2 citations
3P0294Diagnostic Value of the MaRIA Index and Its Correlation with Clinical and Biochemical Parameters in Patients with Crohn’s DiseaseOriginal Research · 2026
4MR Enterography Scores Correlate with Degree of Mucosal Healing in Pediatric Crohn’s Disease: A Pilot StudyOriginal Research · 2023 · 6 citations
5Transmural healing is significantly associated with prevention of clinical relapse in Crohn’s diseaseCohort Study · 2026

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A simple MR enterography assessment of Crohn disease activity based on the most affected bowel segment: A retrospective cohort study2026

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