Randomized trial evaluates antimicrobial activity of synthesized chlorinated chalcone derivatives, suggesting potential uses in medicine.
A series of chlorinated chalcone derivatives containing oxazole and thiazole rings were synthesized via Claisen–Schmidt condensation of 6-acetyl-2(3H)-benzoxa(thia)zolone with substituted chlorobenzaldehydes. The synthesized compounds were evaluated for their antimicrobial activity against selected bacterial and fungal strains. Several compounds demonstrated moderate antimicrobial activity against the tested microorganisms.
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Ivanova et al. (2026) studied this question.
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