Key result
Echocardiographic phenotyping in sepsis requires careful consideration of sample size, right ventricular parameters, and assessment timing to ensure valid prognostic interpretations.
This commentary highlights methodological limitations in a recent study on echocardiographic phenotypes in sepsis, emphasizing the need for standard right ventricular parameters and serial assessments to avoid misclassification.
In this comment, we aim to provide a perspective on the study by Shvilkina et al. entitled “Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis”. After summarizing the principal findings, we discuss several issues related to the interpretation of cluster-based phenotypes. These considerations highlight important methodological limitations that may influence the validity and clinical applicability of the proposed phenotypes.
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Trieu et al. (2026) conducted a letter in Sepsis. Echocardiographic phenotyping was evaluated. Echocardiographic phenotyping in sepsis requires careful consideration of sample size, right ventricular parameters, and assessment timing to ensure valid prognostic interpretations.
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