Key result
Bioactive functional diet yields ~14 kg greater weight loss post-intragastric balloon vs. standard diet.
Why the study?
Because adiposopathy and obesity cause chronic inflammation and increase cardiovascular risk, researchers investigated using bioactive dietary components after bariatric surgery to modulate cardiovascular and prothrombotic parameters.
Does a functional diet enriched with bioactive components and n-3 fatty acids improve fat reduction and cardiovascular parameters in obese women after bioenteric intragastric balloon surgery?
Cohort (n=60)
Open-label
No
Does a functional diet enriched with bioactive components and n-3 fatty acids improve fat reduction and cardiovascular parameters in obese women after bioenteric intragastric balloon surgery?
Supplementing a post-bariatric reduction diet with functional antioxidant and n-3 fatty acid components significantly enhances weight loss and improves markers of cardiovascular risk and thrombosis in obese women.
Answers are grounded in this paper and cite their sources.
Supports bioactive diet post-balloon for greater weight loss in obese women; hypothesis-generating for CV benefits, needing RCTs before practice change.
Background/Objectives: Adiposopathy is the cause of many secondary disorders in the function and structure of many organs and systems in the body. In the progression of obesity and the increasing dysfunction of anti-inflammatory me-diators, chronic inflammation occurs. This may be accompanied by the development of metabolic complications. Methods: A diet with highly bioactive properties was formulated, and an element of diet therapy was introduced as a key component to support treatment in obese patients following bariatric surgery. Patients underwent a BIB (Bioenteric Intragastric Balloon) procedure. As obesity is a risk factor for cardiovascular diseases, this study aimed to regulate cardiovascular factors in adiposopathy. Anti-inflammatory dietary components with modulating properties were included, with increased bioflavonoids, vitamins A, E, C, folic acid, and synbiotics, and altered fatty acid composition. Results: The results showed satisfactory effects on fat reduction and the regulation of isoprostanes, plasminogen, angiotensin, prostacyclin, triglycerides, blood pressure, and blood rheology parameters. Cardiovascular co-morbidities are common in obesity. This is due to the endocrine function of adipocytes. As such, we decided to investigate the possibility of using bioactive dietary components as an adjunct to the safety of reducing prothrombotic parameters in obese patients after BIB surgery. This study hypothesised that the enrichment of the recommended diet after bariatric surgery with the addition of n-3 EFAs, bioflavonoids, vitamins, and synbiotics might result in comparable or greater fat mass loss in the subjects. In addition, the use of a functional diet might show a beneficial modifying effect on antihyperglycemic parameter values. We then compared the results to those obtained among patients fed a reducing, standard diet. Conclusions: Using a functional diet, a significant reduction in visceral fat was achieved. A decrease in VFA was shown to reduce whole-blood viscosity. Furthermore, this study showed a significant effect of bioactive components on pro-thrombotic parameters in obese patients.
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Balejko et al. (2024) conducted a cohort in Obesity with hypertension (n=60). Functional reduction diet (enriched with bioflavonoids, vitamins, flaxseed oil n-3 EFAs, and synbiotics) vs. Standard reduction diet (Group II) and non-compliant control group (Group I) was evaluated on Mean post-treatment body weight (kg) (p=<0.05). A functional diet enriched with bioactive ingredients after intragastric balloon surgery resulted in greater weight loss (average reduction of 28.5 kg vs 15.0 kg) and significantly improved cardiovascular and prothrombotic parameters compared to a standard reduction diet.
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