Key result
Recent structural data on large NH2-terminal regions of IP3Rs and RyRs and their tetrameric arrangement reveal striking mechanistic similarities in calcium release channel function.
Highlights the structural and mechanistic similarities between IP3Rs and RyRs, underscoring their shared evolutionary origin.
Suggests opportunities for dual-targeting calcium release channels; leaves open clinical translation to cardiovascular therapies.
Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.
No takes yet. Share an insight, caveat, or question.
Stathopulos et al. (2012) reported a review. Recent structural data on large NH2-terminal regions of IP3Rs and RyRs and their tetrameric arrangement reveal striking mechanistic similarities in calcium release channel function.
Synapse has enriched one closely related paper. Consider it for comparative context: