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July 9, 2026MedicinesOpen Access

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021–2025): Pharmaceutical Use, Trends and Synthetic Approaches

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DTDavide Benedetto Tiz

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Overview

Review analyzes FDA-approved drugs with amide functionality, highlighting implications for drug design and discovery.

Key Points

  • This review aims to analyze the role and trends of FDA-approved drugs containing amide functionality from 2021 to 2025.
  • Review of FDA-approved small molecules and peptides with MW < 1300 Da from 2021 to 2025.
  • Analysis of functional versatility of amide bonds in different therapeutic areas.
  • Detailed examination of synthetic routes and amide-forming strategies for each drug.
  • Amides serve as crucial components in antiviral agents like nirmatrelvir, enhancing binding affinity to viral proteases.
  • In oncology, drugs like adagrasib utilize amides for selective inhibition of mutant kinases.
  • The review emphasizes the enduring and evolving importance of amide functionality in next-generation therapeutics.

Cite This Study

Davide Benedetto Tiz (2026) studied this question.

synapsesocial.com/papers/6a4f3c252b81a944af575b4bhttps://doi.org/10.3390/medicines13030022
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