Key result
Hypothyroidism is linked to thoracic aortic aneurysm and dissection and worse prognosis after acute dissection.
Why the study?
Numerous studies have proposed a pathophysiological role for hypothyroidism in the development of thoracic aortic aneurysms and dissections, but this role is still not fully understood.
Is hypothyroidism associated with the development and prognosis of thoracic aortic diseases?
Is hypothyroidism associated with the development and prognosis of thoracic aortic diseases?
Hypothyroidism may be a risk factor for thoracic aortic diseases and a negative prognostic indicator after acute aortic dissection, suggesting a potential role for thyroid function screening in these patients.
Abstract Background Thoracic aortic aneurysms (TAA) and aortic dissections (AD) are recognized as one of the leading causes of death in developed countries. Although mortality decreases if at-risk individuals are diagnosed early on through screening, many fail to seek the proper preventive interventions timely. Genetic predisposition, smoking, and hypertension are well-known risk factors for highly lethal aortic aneurysmal rupture or dissection. Hypothyroidism has also been extensively described in the literature as a possible risk factor directly related to the origin of thoracic aortic aneurysm and dissection. Numerous studies have proposed a pathophysiological role for hypothyroidism in the development of TAA and AD, although this role is still not fully understood. Objective This scoping review sought human and animal studies to examine the relationship between hypothyroidism and thoracic aortic diseases. Methods A search in PubMed, Web of Science, and Scopus using the terms "aortic dissection," "aorta," "aortic aneurysm," and "hypothyroidism" yielded 907 articles, and only nine were relevant to this study topic and criteria. Results The included articles discuss thoracic aortic diseases as potential risk factors for thoracic aortic aneurysm and dissection. A low thyroid hormone level might be a negative prognostic indicator after acute aortic dissection. Conclusion Establishing a link between hypothyroidism and thoracic aortic diseases could improve clinical practice through the development of screening strategies for thyroid function in patients with thoracic aortic diseases, thereby reducing postoperative mortality rates.
No takes yet. Share an insight, caveat, or question.
Hamzah et al. (2025) conducted a review in Thoracic aortic diseases and hypothyroidism. Hypothyroidism was evaluated on Relationship between hypothyroidism and thoracic aortic diseases. A scoping review of 9 studies identified hypothyroidism as a potential risk factor for thoracic aortic aneurysm and dissection, and a possible negative prognostic indicator after acute dissection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: