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July 9, 2026CirculationOpen Access

Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1–Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation

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Authors

GCGillian CockerillTHTanya Y. HuehnsAWArjuna Weerasinghe

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Overview

Randomized trial investigates the effect of elevated HDL on E-selectin in inflammation, suggesting potential anti-inflammatory benefits.

Key Points

  • The study aims to determine whether elevating plasma HDL levels inhibits endothelial cell activation in vivo.
  • Utilized a porcine model of acute inflammation induced by interleukin-1alpha.
  • Measured E-selectin expression using a radiolabeled anti-E-selectin antibody.
  • Elevated HDL levels through a bolus injection of reconstituted discoidal HDL.
  • Reconstituted HDLs inhibited IL-1alpha-induced E-selectin expression in vitro.
  • Elevating HDL levels approximately 2-fold significantly reduced E-selectin expression in vivo.
  • The inhibitory effect on E-selectin expression was consistent across endothelial cells, confirming broader applicability.

Cite This Study

Cockerill et al. (2001) studied this question.

synapsesocial.com/papers/6a501048005270d31ee7fc33https://doi.org/10.1161/01.cir.103.1.108
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