What is the clinical evidence from this study?

Study design: Observational. Population: Erythermalgia (n=51). Intervention: Erythermalgia. Primary outcome: Clinical characteristics and associated conditions.

What question did this study set out to answer?

The study aims to delineate the features of erythermalgia and its association with myeloproliferative disorders.

July 10, 2026Circulation

Erythermalgia

Q: What does this research mean for the field?

Erythermalgia presents as either a primary syndrome in younger patients or a secondary condition that is significantly associated with myeloproliferative disorders, which it can precede by up to 12 years. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Primary erythermalgia presents with more severe bilateral pain, while secondary disease is linked to myeloproliferative disorders.

n=51

Key Points

The study aims to delineate the features of erythermalgia and its association with myeloproliferative disorders.
Clinical assessment of 51 erythermalgia patients at the Mayo Clinic between 1951 and 1960.
Classification of patients into primary and secondary erythermalgia based on associated conditions.
Analysis of the symptom profile related to environmental temperature and skin cooling measures.
30 patients diagnosed with primary erythermalgia, showing more intense pain and bilateral symptoms.
10 cases of erythermalgia linked to myeloproliferative disorders, some presenting 12 years before other symptoms appeared.
Primary erythermalgia primarily affects younger individuals and involves larger affected areas.

Study Design

Type

Observational (n=51)

Multicenter

Structured PICO

Population

51 patients with erythermalgia seen at the Mayo Clinic between 1951 and 1960.

Outcome

Clinical characteristics and disease associations (primary vs secondary erythermalgia)

Discussion

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Implication

Erythermalgia can be primary or secondary, with secondary cases frequently associated with myeloproliferative disorders that may manifest years later.

Cite This Study

Babb et al. (1964) conducted an observational in Erythermalgia (n=51). Erythermalgia was evaluated on Clinical characteristics and associated conditions. Among 51 patients with erythermalgia, 30 had primary disease with more intense, bilateral pain in younger individuals, while secondary disease was linked to myeloproliferative disorders in 10 cases.

synapsesocial.com/papers/6a5064ae330ff8da2846ea6b https://doi.org/10.1161/01.cir.29.1.136

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Implication

Erythermalgia can be primary or secondary, with secondary cases frequently associated with myeloproliferative disorders that may manifest years later.