Study on drug loading and release properties of post-synthetic modified core-shell aluminum-based MOFs materials

Metal-Organic Frameworks (MOFs), as a new type of metal nanomaterials characterised by high porosity and specific surface area, exhibit significant potential for drug delivery. In this study, a core-shell structured aluminium-based MOF material was synthesised by one-pot reaction and the release performance of MMOFs was explored. Carboxyl groups were introduced into the MMOFs by Post-Synthetic Modification (PSM) of glutamic acid (Glu), aspartic acid (Asp), and glutaric anhydride. The successful preparation of the PSM materials was confirmed through characterisation using Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). After loading aspirin onto the three materials, in vitro release experiments were conducted in PBS buffer. The release results were measured by fluorescence spectrophotometry which demonstrated that the in vitro drug release properties of the MMOFs could be affected by various post-synthetic modifications, potentially leading to accelerated drug release or reduced drug loading capacity.