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July 10, 2026BMC GenomicsOpen Access

Harnessing probiotics to combat nonylphenol toxicity: a multiomics approach of gut microbiome remodelling in Silurus meridionalis

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Authors

DLDeqin LuoGuizhou UniversityFLFanglian LuGuizhou UniversityLYLian YangGuizhou University

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Implication

Randomized trial shows probiotics improve growth and gut health in Silurus meridionalis, suggesting new strategies for aquaculture.

Key Points

  • This study investigates the effectiveness of probiotics in mitigating nonylphenol toxicity in Silurus meridionalis.
  • Fish received 7 weeks of probiotic treatment followed by 15 days of nonylphenol exposure.
  • Integrated multiomics analyses included metagenomics, transcriptomics, and metabolomics.
  • Validation was performed using RT‒qPCR and ELISA techniques.
  • Nonylphenol exposure significantly reduced weight gain and specific growth rates.
  • Probiotic treatment restored weight gain and specific growth rates, reversing toxic effects.
  • Multiomics analysis revealed enhanced short-chain fatty acid synthesis and activation of lipid metabolism pathways.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6a508b966eeac72a437a032bhttps://doi.org/10.1186/s12864-026-13161-4
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