This article reviews physiological mechanisms of interstitial fluid dynamics and lymphatic drainage in the interstitial compartment, implying improved understanding of bodily fluid circulation.
The proposal of a "new third bodily system for circulation of fluid" has been recently put forward. The present article sheds light on all available physiological knowledge concerning exactly this same space, defined as "interstitial compartment" as originally hypothesized by Ernest Starling about 130 years ago. We provide here a brief updated summary of the main morpho-functional features and corresponding analysis concerning capillaries microfiltration, interstitial fluid dynamics, and lymphatic drainage.
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Negrini et al. (2026) studied this question.
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