Answers are grounded in this paper and cite their sources.
Demonstrates the synthesis of diverse amides using palladium-catalyzed coupling, highlighting practical applications in drug development.
-(diphenylphosphinyl)hydroxylamine (DPPH), allows access to a broad scope of secondary amides bearing aromatic and olefinic groups, including enamides, α,β-unsaturated amides, and α,β-unsaturated enamides. Drug-like analogs can be rapidly assembled, and we show that "reverse amide" counterparts can be generated from the same starting materials.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2026) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: