Key result
Female sex in TAAD links to less treatment, worse outcomes, and aortic complications during pregnancy.
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Why the study?
Women with thoracic aortic aneurysm and dissection have lower treatment rates and worse outcomes despite higher prevalence in men, and pregnancy carries increased aortic complication risks.
Answers are grounded in this paper and cite their sources.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Despite its higher prevalence among men, women with thoracic aortic aneurysm and dissection (TAAD) have lower rates of treatment and surgical intervention and often have worse outcomes. Understanding sex-specific differences in TAAD has the potential to improve care delivery, reduce disparities in treatment, and optimize outcomes for women with TAAD.”
“The prevalence of aortic disease is not as common among women. But when it does occur in women, they tend to do worse. So we need to ask ourselves, what can we do to improve the care of these patients?”
“We think that estrogen, which women have, is helpful in protecting their aorta from not tearing or dilating. But that can change after menopause, when women lose their estrogen.”
May warrant attention to sex disparities in thoracic aortic disease care; leaves open validation in prospective studies.
Despite its higher prevalence among men, women with thoracic aortic aneurysm and dissection (TAAD) have lower rates of treatment and surgical intervention and often have worse outcomes. A growing number of women with TAAD also desire pregnancy, which can be associated with an increased risk of aortic complications. Understanding sex-specific differences in TAAD has the potential to improve care delivery, reduce disparities in treatment, and optimize outcomes for women with TAAD.
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Crousillat et al. (2023) conducted a review in Thoracic aortic aneurysm and dissection (TAAD). Female sex vs. Male sex was evaluated. Female sex in thoracic aortic aneurysm and dissection is associated with lower rates of treatment, worse outcomes, and increased risk of aortic complications during pregnancy compared to men.
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