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July 11, 2026NeurophotonicsOpen Access

Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging

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Authors

MFMorgan FogartySFSilvina L. FerradalRDRajat Dhar

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Overview

Proof-of-principle trial demonstrates disrupted brain connectivity detection in stroke patients using optical imaging tools, suggesting better assessment methods for neurological recovery.

Key Points

  • The study aims to evaluate the sensitivity of a functional connectivity metric using optical imaging to assess brain function during ischemic stroke recovery.
  • Conducted a proof-of-principle study with 13 ischemic stroke patients within 72 hours of last known normal.
  • Utilized high-density diffuse optical tomography (HD-DOT) to measure cortical oxygenation and developed a similarity metric to assess functional connectivity (FC).
  • Compared FC in stroke patients to healthy controls and older healthy cohorts, using the NIH Stroke Scale to evaluate functional disruptions.
  • The FC Similarity metric showed significant sensitivity to the presence of a stroke with Cohen’s d=1.5, p=1.2×10−3.
  • A significant relationship was found between FC Similarity and neurological disruption (R2=0.69, p=4.7×10−4).
  • The findings support using HD-DOT and the FC Similarity metric for acute stroke recovery assessments.

Cite This Study

Fogarty et al. (2026) studied this question.

synapsesocial.com/papers/6a51dd5ac18d7f28ca4ffeaahttps://doi.org/10.1117/1.nph.13.3.035002
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