In this research, methyliminopyridopyrimidines were synthesized in high yields via employing guanidine, activated acetylenic substances, α,β-unsaturated compounds, and methyl iodide in the presence of catalytic amounts of Bio-APTES@SiO 2 @Fe 3 O 4 -SO 3 H in water at room temperature in 2 h. The APTES@SiO 2 @Fe 3 O 4 -SO 3 H, was synthesized employing water extract of rhizome of Petasites hybridus as green medium. The rhizome of Petasites hybridus water extract is as stabilizing and reducing agents and in this medium the yields of nanocatalyst are higher relative to water medium. Another goal in this project is investigation of the antioxidant capacity using DPPH radical scavenging and the reduction of ferric ions (Fe 3+ ) assays. This study indicates that, amongst the four test compounds, 5c showed highest antioxidant activity with IC 50 at 12.56 μg/mL, in comparison to those of the standard BHT and TBHQ at 9.26 and 8.75 μg/mL respectively for the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. The disk diffusion method was utilized in order to carry out a methodical evaluation of the antibacterial activity of the compounds that were created. Through the utilization of this methodology, tests were carried out against two unique strains of Gram-negative bacteria in addition to Gram-positive bacteria. The methyliminopyridopyrimidines 5b, 5c, 5e, 5f, 5i, and 5j showed strong antibacterial properties that were efficient against Gram-positive as well as Gram-negative bacteria. Also, the catalytic activity of the green synthesized Bio-APTES@SiO 2 @Fe 3 O 4 -SO 3 H was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions which high and effective catalytic activity for organic pollutants within few seconds. The approach of synthesis that was applied for the development of methyliminopyridopyrimidine was marked by a confluence of good properties.
Shirangi et al. (Thu,) studied this question.