⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 9, 2026HaematologicaOpen Access

Genetic screening of triple negative thrombocytosis patients identifies germline MPL compound mutations and SH2B3/LNK truncating mutations

Bruno Cassinat Louise Lecordier Sarah Awan-Toor Denis Clay Diego Elrio Emmanuelle Verger Rafael Daltro De Oliveira Hélène Pasquer Lina Benajiba Nelly Bosselut Ludovic Drouet Juliette Soret Thierry Leblanc Luc Darnige L P Zhao Damien Luque Paz Françoise Boyer Éric Lippert Louis Drevon Stephane Giraudier Jean‐Jacques Kiladjian Nabih Maslah Laura Velazquez

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to identify the genetic mutations present in patients with triple negative thrombocytosis.
Screened patients with triple negative thrombocytosis for genetic mutations
Analyzed specific genes including MPL, SH2B3, and LNK
Identified compound mutations in the MPL gene in a subset of patients
Detected truncating mutations in the SH2B3 and LNK genes in several cases

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Genetic screening reveals germline and truncating mutations in triple negative thrombocytosis, suggesting novel pathways for diagnosis and treatment.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Cassinat et al. (2026) studied this question.

synapsesocial.com/papers/6a51dd5ac18d7f28ca4fffdd https://doi.org/10.3324/haematol.2026.300850

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Beyond triple-negative: germline MPL and SH2B3/LNK mutations reshape the genetic landscape of hereditary thrombocytosisOriginal Research · 2026
2Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patientsCohort Study · 2015 · 197 citations
3Triple-negative myeloproliferative neoplasms (TN-MPN): A meta-analysis of clinical and molecular characteristics2025 · 1 citations
4Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transferpreclinical · 1996 · 88 citations
5Abstract 5956: <i>FLT3</i> alterations and inhibition in triple negative B-cell adult acute lymphoblastic leukemia patients2024

More related papers

<i>TP53</i> mutation screening for patients at risk of myeloid malignancy.2024
Clinical utility of investigations in triple‐negative thrombocytosis: A real‐world, multicentre evaluation of <scp>UK</scp> practice2024
First Report of MPL c.23T>G (p.M8R) Variant in Congenital Amegakaryocytic Thrombocytopenia: A Case Report2025

More from Haematologica

Venetoclax plus azacitidine in younger adults with acute myeloid leukemia beyond historical comparisons. Comment on: "Venetoclax and azacitidine for younger acute myeloid leukemia patients independent of fitness for intensive chemotherapy"Thu,
Effects of secondary factor VIII prophylaxis on joint and bone health in a hemophilia A mouse modelThu,