Nanopolymer wound matrix for secondary intention healing – A twin lesion report

A fully synthetic nanopolymer wound matrix that mimics the native extracellular matrix has emerged as a promising tool for accelerating secondary intention wound healing. We present the case of a 63-year-old female who underwent Mohs micrographic surgery resulting in two adjacent twin defects on the right chest. Defect (I) was treated with petrolatum ointment and defect (II) was treated with a nanopolymer wound matrix sheet. By week 2, the matrix-treated wound had completed granulation by 80% while the petrolatum-treated wound continued to granulate. Modified Manchester Scar Scale scores were lower for the matrix-treated wound at both week 5 (8 vs. 10) and week 8 (7 vs. 8), with no complications reported in either wound. This case highlights the potential of a fully synthetic, resorbable nanopolymer scaffold to improve both the speed and quality of secondary intention healing compared to standard moist wound care.