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July 11, 2026Journal of Environmental Science and Health Part A

In vivo assessment of naringenin-mediated amelioration of lead-induced testicular injury in rats: regulation of Nrf2/Keap1 and PINK1/Parkin pathways

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Authors

JZJing ZhuHenan University of Science and TechnologyMGMengmeng GaoHenan University of Science and TechnologyHLHao LingHenan University of Science and Technology

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Implication

Randomized trial examines naringenin's protective effects on testicular injury in rats, highlighting novel cellular mechanisms.

Key Points

  • The aim is to evaluate the protective role of naringenin against lead-induced testicular injury and determine its impact on specific cellular pathways.
  • Male SD rats were exposed to lead (60 mg/kg) and co-treated with naringenin (50 mg/kg) for 8 weeks.
  • Biochemical detection, oxidative stress evaluation, and molecular analyses including qPCR and WB were performed to assess the impacts.
  • Histopathological observation and hematological examinations were conducted to evaluate testicular damage.
  • Lead exposure resulted in significant hematological disturbances and oxidative stress (reduced GSH, SOD, CAT; increased MDA).
  • Naringenin co-treatment restored serum reproductive hormones and improved mitochondrial clearance through the PINK1/Parkin pathway.
  • Activation of the Nrf2/Keap1 axis by naringenin significantly mitigated oxidative stress-related testicular damage.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a51df22c18d7f28ca50084dhttps://doi.org/10.1080/10934529.2026.2699582
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