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July 11, 2026Mutagenesis

Antioxidant and Geno-protective Effects of Naturally Occurring Delphinidin Glycosides

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Authors

GMGiorgia MartelliCLCarima LörchNHNaji Said Aboud Hadi

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Overview

Randomized trial investigates antioxidant effects of delphinidin glycosides in human cells, indicating dietary implications.

Key Points

  • This study aims to explore how glycosylation affects the antioxidant and DNA-protective effects of delphinidin and its derivatives.
  • Compared aglycone delphinidin with glycosylated derivatives and Maqui berry extract.
  • Assessed oxidative stress in Caco-2 cells using hydrogen peroxide and DCFH₂-DA.
  • Evaluated DNA protection and geno-protection using comet assay and micronucleus assay in HepG2 cells.
  • Delphinidin and glycosides significantly reduced intracellular ROS and protected against oxidative DNA damage.
  • Protective effects were sustained even after medium replacement, implying effective cellular uptake.
  • Delphinidin and its glycosides reduced geno-toxicity from riddelliine exposure, interfering with metabolic activation.

Cite This Study

Martelli et al. (2026) studied this question.

synapsesocial.com/papers/6a51e019c18d7f28ca500a8dhttps://doi.org/10.1093/mutage/geag027
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