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July 11, 2026Drug and Chemical Toxicology

Decoding the role of phthalate plasticizers (DBP, DOP, and DEHP) in idiopathic pulmonary fibrosis: an integrated network toxicology and machine learning approach

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Authors

FWFan WuBLBangdong LiuFZFengjun Zhang

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Overview

This research investigates the role of phthalate plasticizers in idiopathic pulmonary fibrosis, suggesting new prevention strategies.

Key Points

  • The research aims to explore how phthalate plasticizers contribute to idiopathic pulmonary fibrosis and identify potential treatment targets.
  • Utilized various databases for target identification, including PubChem and GEO.
  • Applied machine learning techniques to refine core targets related to plasticizers and IPF.
  • Conducted molecular docking to evaluate binding affinity between PAEs and key targets.
  • Identified 15 potential targets for PAEs related to IPF, narrowing it down to 10 core targets.
  • Functional enrichment analysis indicated the Toll-like receptor and IL-17 signaling pathways are crucial in IPF development.
  • Confirmed strong binding interactions between DBP, DOP, DEHP, and the identified core targets through molecular docking.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a51e019c18d7f28ca500b22https://doi.org/10.1080/01480545.2026.2700652
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