Key result
Recent genome-wide association studies combined with ECG data have identified novel genomic regions implicated in ECG variability and cardiac conduction system function.
Recent genome-wide association studies combined with ECG data have expanded our understanding of the genetic basis of cardiac conduction system function.
Loci tied to ECG variability merit functional validation; leaves open clinical utility for conduction disease risk prediction.
Proper function of an organized Cardiac Conduction System (CCS) is vital to the survival of metazoans ranging from fly to man. The routine use of non-invasive electrocardiogram measures in the diagnosis and monitoring of cardiovascular health has established a trove of reliable CCS functional data in both normal and diseased cardiac states. Recent combination of echocardiogram (ECG) data with genome-wide association studies has identified genomic regions implicated in ECG variability which impact CCS function. In this study, we review the substantial recent progress in this area, highlighting the identification of novel loci, confirming the importance of previously implicated loci in CCS function, and exploring potential links between genes with important roles in developmental processes and variation in function of the CCS.
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Arnolds et al. (2011) conducted a review in Cardiac conduction system function and ECG variability. Recent genome-wide association studies combined with ECG data have identified novel genomic regions implicated in ECG variability and cardiac conduction system function.
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