Improved VO ₂ max following anti-IL-5 therapy in severe eosinophilic CRSwNP: exploratory associations with cardiac inflammatory biomarkers

Jens Even Tidemandsen; K Rossing; Anne Sophie Homøe; Morten Hostrup; Vibeke Backer

doi:10.1080/20018525.2026.2700828

July 9, 2026European Clinical Respiratory JournalOpen Access

Improved VO ₂ max following anti-IL-5 therapy in severe eosinophilic CRSwNP: exploratory associations with cardiac inflammatory biomarkers

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Key Points

The aim is to explore the effects of anti-IL-5 therapy on VO2 max and its association with cardiac inflammatory biomarkers in severe eosinophilic CRSwNP.
Exploratory associations examined between VO2 max and inflammatory biomarkers after anti-IL-5 therapy.
Participants had severe eosinophilic chronic rhinosinusitis with nasal polyps.
VO2 max significantly improved post anti-IL-5 therapy, indicating enhanced cardiovascular fitness.
Specific cardiac inflammatory biomarkers showed positive changes, suggesting a reduction in systemic inflammation.

Implication

Finds improved VO2 max in severe eosinophilic CRSwNP with anti-IL-5 therapy, suggesting potential cardiovascular benefits.

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist [1], driven by type 2 inflammation involving eosinophils, interleukin-5 (IL-5), and systemic immune activation [2,3]....

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Cite This Study

Tidemandsen et al. (2026) studied this question.

synapsesocial.com/papers/6a532e014f7abc118adec9fd https://doi.org/10.1080/20018525.2026.2700828

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Improved VO ₂ max following anti-IL-5 therapy in severe eosinophilic CRSwNP: exploratory associations with cardiac inflammatory biomarkers

Key Points

Implication

Abstract

Discussion

Cite This Study

Improved VO ₂ max following anti-IL-5 therapy in severe eosinophilic CRSwNP: exploratory associations with cardiac inflammatory biomarkers

Key Points

Implication

Abstract

Discussion

Cite This Study

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