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July 12, 2026Cell Death and DifferentiationOpen Access

Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation

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Authors

YYYuelong YanLZLi ZhuangBGBoyi Gan

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Overview

Exploration of disulfidptosis and its role in cellular response to nutrient deprivation highlights key regulatory pathways.

Key Points

  • Investigate whether disulfidptosis is a direct result of glucose deprivation or regulated by stress responses.
  • Explored the biochemical mechanisms underlying disulfidptosis.
  • Analyzed the role of SLC7A11 in nutrient deprivation-related cell death.
  • Assessed the impact of disulfidptosis on actin cytoskeleton integrity.
  • Disulfidptosis characterized by cytoskeleton collapse due to disulfide stress.
  • High SLC7A11 expression leads to increased cystine uptake and NADPH depletion.
  • Disulfidptosis represents a distinct metabolic cell death pathway from apoptosis and necroptosis.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a532e014f7abc118adeca43https://doi.org/10.1038/s41418-026-01817-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanistic insights into disulfidptosis in cancer and therapeutic opportunities2026 · 2 citations
  2. 2Disulfidptosis: A Metabolic Cell Death Mechanism with Therapeutic Potential in Cancer2026 · 3 citations
  3. 3The emerging role of disulfidptosis in metabolic synergistic death and cancer immunotherapy2026 · 2 citations
  4. 4Disulfidptosis: disulfide stress‐induced novel cell death pathway2024 · 4 citations
  5. 5Disulfidptosis vs. Ferroptosis: A Comprehensive Review of SLC7A11-Mediated Metal Dyshomeostasis and Cell Death2026 · 1 citations