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July 9, 2026The Journal of Japanese College of AngiologyOpen Access

Catheter-Directed Thrombolysis with Tissue-Type Plasminogen Activator for Japanese Patients with Thrombotic Lower Limb Arterial Occlusion

Hitoshi Anzai Keigo KAJIWARA Hiroya Watanabe R. Saito T Katou Mitsuyo Ito Y Samejima Chihiro Fukuyama Kento Yabe Hiroki Takenaka Naohiko Nemoto

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Key Points

To examine the outcomes of catheter-directed thrombolysis using alteplase for treating thrombotic lower limb arterial occlusion in Japanese patients.
Cohort of 18 patients (mean age 68 years) undergoing catheter-directed thrombolysis with alteplase.
Median duration of treatment was 1 day (range 1-3 days).
Alteplase was infused at a dose of 0.0087 mg/kg/hr.
Successful reperfusion was achieved in 17 patients with a TIPI score of 2 or higher.
A major limb adverse event occurred in 1 patient leading to amputation.
7 instances of BARC 3a or b bleeding complications were noted.

Implication

Evaluates outcomes of catheter-directed thrombolysis in Japanese patients, highlighting effectiveness in restoring blood flow.

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Cite This Study

Anzai et al. (2026) studied this question.

synapsesocial.com/papers/6a532e624f7abc118adecc21 https://doi.org/10.7133/jca.26-00002

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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