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July 9, 2026European Journal of Preventive Cardiology

Rheumatoid arthritis and risk of myocardial infarction: A nationwide cohort study

In Young Cho Jin Hyung Jung Seonyoung Kang S.P. Kim Wonyoung Jung Alicia Shin Hyungjin Kim Kyungdo Han Dong Wook Shin

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Key Points

This study aims to evaluate the risk of myocardial infarction (MI) in individuals with rheumatoid arthritis (RA) and analyze the impact of biologic and targeted synthetic DMARDs.
Retrospective cohort study using the Korean National Health Insurance System database.
Included patients aged ≥ 40 years newly diagnosed with RA, matched 1:3 with non-RA controls, totaling 145,508 participants.
Statistical analysis performed using Fine and Gray subdistribution hazard models to estimate event risks.
Patients with RA had a 1.8-fold increased risk of MI compared to non-RA (sHR: 1.84, 95% CI: 1.67–2.01).
Both seronegative RA (sHR: 1.74, 95% CI: 1.49–2.04) and seropositive RA (sHR: 1.87, 95% CI: 1.69–2.07) showed similar elevated risks.
Non-use of tsDMARDs was associated with increased MI risk (sHR: 1.86, 95% CI: 1.77–1.96) while tsDMARD use did not show significant association (sHR: 1.43, 95% CI: 0.90–2.28).

Implication

Retrospective cohort study finds increased myocardial infarction risk in rheumatoid arthritis, indicating potential clinical implications.

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Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/6a5331064f7abc118aded790 https://doi.org/10.1093/eurjpc/zwag358

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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