Why the study?
Pituitary apoplexy is a rare endocrine emergency that may precipitate Takotsubo cardiomyopathy, with only approximately 30 cases of this association reported worldwide.
Case Report (n=1)
Pituitary apoplexy can rarely precipitate reversible Takotsubo cardiomyopathy, which can be successfully managed with prompt endocrine resuscitation and goal-directed perioperative management.
May support endocrine resuscitation for pituitary apoplexy with cardiomyopathy; hypothesis-generating and leaves open need for prospective confirmation.
Pituitary apoplexy is a rare endocrine emergency that may precipitate Takotsubo (stress-induced) cardiomyopathy, a transient left ventricular dysfunction frequently misdiagnosed as acute coronary syndrome. Approximately 30 cases of this rare association have been reported worldwide. We report a 45-year-old man presenting with pituitary apoplexy and panhypopituitarism complicated by severe left ventricular dysfunction (ejection fraction 27%) with classic apical ballooning. Diagnosis was established using modified Mayo Clinic criteria. Following emergent endocrine resuscitation, he underwent successful endoscopic endonasal resection under general anesthesia with goal-directed hemodynamic monitoring. The perioperative course was uneventful; follow-up echocardiography at 4 weeks demonstrated complete cardiac recovery (ejection fraction 48%). This case highlights the importance of early suspicion, prompt endocrine resuscitation, and coordinated multidisciplinary perioperative management in this rare but life-threatening association.
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Parameswaran et al. (2026) conducted a case report in Pituitary apoplexy with stress cardiomyopathy (Takotsubo syndrome) (n=1). Endocrine resuscitation and endoscopic endonasal resection was evaluated on Left ventricular ejection fraction.
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