Newly diagnosed mental disorders in permanent pacemaker patients were associated with higher 10-year all-cause mortality compared to those without mental disorders (HR 1.71; 95% CI 1.61-1.82).
Cohort (n=78,388)
Yes
Does the presence of newly diagnosed mental disorders increase long-term mortality in patients with a permanent pacemaker?
Newly diagnosed mental disorders in patients with permanent pacemakers are associated with significantly increased long-term mortality, particularly in younger men and those with early-onset mental disorders.
Hazard Ratio: 1.71 (95% CI 1.61–1.82)
Absolute Event Rate: 53.6% vs 31.3%
BACKGROUND: The burden of mental disorders among patients with permanent pacemakers (PPMs) and their impact on long-term outcomes remain poorly understood. We aimed to investigate the incidence of newly diagnosed mental disorders among PPM patients and to evaluate their prognostic implications. METHODS: From the Korean National Health Insurance Service database, we identified 19 746 patients who underwent PPM implantation and 58 642 propensity score-matched controls without a PPM between 2010 and 2020. Among PPM patients, long-term clinical outcomes were compared according to the presence of newly diagnosed mental disorders. RESULTS: The 10-year cumulative incidence of any newly diagnosed mental disorders among PPM patients was 45.1%. The most common mental disorders were depressive disorder (24.6%), insomnia (20.6%), and anxiety disorder (5.6%). The overall risk of detecting new mental disorders among PPM patients was similar to that of the matched general population (hazard ratio HR, 0.98 95% CI, 0.96-1.01). However, male PPM patients showed a significantly higher risk, particularly those aged <50 years (HR, 1.42 95% CI, 1.16-1.75) and those aged 50 to 59 years (HR, 1.20 95% CI, 1.04-1.38). PPM patients diagnosed with any mental disorder had a significantly higher 10-year cumulative all-cause mortality compared with those without mental disorders (53.6% versus 31.3%; HR, 1.71 95% CI, 1.61-1.82), with the highest risk observed in patients with schizophrenia (HR, 3.23 95% CI, 2.61-4.00). Adverse outcomes were more pronounced in male patients and when mental disorders were diagnosed early after implantation (within 3.2 years). CONCLUSIONS: Although the risk of detecting new mental disorders among PPM patients was comparable to that of the matched non-PPM population, newly diagnosed mental disorders were associated with increased long-term mortality in PPM patients, particularly in younger men and those with early-onset mental disorders.
Kim et al. (Fri,) conducted a cohort in Permanent pacemaker (PPM) (n=78,388). Newly diagnosed mental disorders vs. No mental disorders was evaluated on 10-year cumulative all-cause mortality (HR 1.71, 95% CI 1.61-1.82). Newly diagnosed mental disorders in permanent pacemaker patients were associated with higher 10-year all-cause mortality compared to those without mental disorders (HR 1.71; 95% CI 1.61-1.82).