Key result
Retinochoroidal microvascular abnormalities persist on angiography despite clinical resolution of lipemia retinalis.
Why the study?
Lipemia retinalis is generally considered benign, but angiographic evidence of retinal pigment epithelium injury after biochemical normalization has not been previously documented in infants.
Case Report (n=1)
No
This case report provides the first angiographic evidence that lipemia retinalis in infants may be associated with persistent retinochoroidal sequelae even after biochemical normalization of severe hypertriglyceridemia.
Answers are grounded in this paper and cite their sources.
Persistent angiographic abnormalities after lipemia retinalis resolution in an infant; challenges benign consensus but leaves open clinical relevance.
Lipemia retinalis (LR) is generally considered a benign ocular manifestation of severe hypertriglyceridemia. However, angiographic evidence of retinal pigment epithelium (RPE) injury after biochemical normalization has not been previously documented in infants. We report the case of a full-term 20-day-old girl who presented with hematochezia and severe hypertriglyceridemia. Fundus examination demonstrated stage 3 LR, with creamy vessels, salmon-colored fundus, and grayish optic disks. Genetic testing identified compound heterozygosity in lipoprotein lipase (p.Trp113Arg [paternal]; p.Met328Ile [maternal]). Despite clinical and biochemical improvement after fasting, intravenous fluids, and exchange transfusion, follow-up fundus and fluorescein angiography revealed persistent patchy choroidal filling delay and multiple discrete hyperfluorescent spots, suggestive of focal RPE injury. This report illustrates that LR may be associated with subtle, lasting retinochoroidal sequelae following resolution.
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Martinuzzi et al. (2026) conducted a case report in Lipemia retinalis and severe hypertriglyceridemia (n=1). Exchange transfusion, fasting, and intravenous fluids was evaluated on Retinochoroidal sequelae on fluorescein angiography. Follow-up fluorescein angiography revealed persistent patchy choroidal filling delay and multiple discrete hyperfluorescent spots despite clinical and biochemical resolution of lipemia retinalis.
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