Key result
Noninvasive endothelial function assessment provides relevant vascular health indices but requires nuanced interpretation of confounders.
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Why the study?
Interpretation of noninvasive vascular endothelial function assessments is complex due to various methodological, physiological, and pathobiological factors, requiring nuanced understanding.
Highlights the methodological, physiological, and pathobiological factors that complicate the interpretation of noninvasive vascular endothelial function assessments.
Noninvasive assessment of vascular endothelial function, most commonly via brachial artery flow-mediated vasodilation and peripheral arterial tonometry-derived reactive hyperemia index, has become a cornerstone of cardiovascular research. These techniques provide clinically relevant surrogate indices of vascular health and have been associated with future cardiovascular risks. However, their interpretation is complex because they are influenced by a wide range of methodological, physiological, and pathobiological factors. A nuanced understanding of these limitations is essential, particularly in mechanistic and intervention studies.
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Yukihito Higashi (2026) reported a review. Noninvasive assessment of vascular endothelial function was evaluated. Noninvasive assessment of vascular endothelial function provides clinically relevant surrogate indices of vascular health but requires nuanced interpretation due to various confounding factors.
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