A novel, magnetically separable nanocomposite was designed and synthesized via the insitu immobilization of Pd nanoparticles on magnetic carbon nanotubes (CNT/Fe 3 O 4 /Pd NPs). The structural and morphological properties of this architecture were comprehensively characterized using field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), elemental mapping, transmission electron microscopy (TEM), and inductively coupled plasma-atomic emission spectroscopy (ICP-AES). TEM study revealed the particle size of Pd NPs was around 25–30 nm. The catalytic efficacy of the heterogeneous system was evaluated in the Buchwald–Hartwig C–N cross-coupling reaction. The catalyst facilitated the high-yield synthesis (85-95%) of diverse aryl amines from aryl halides (Cl, Br, I) and demonstrated excellent stability, allowing for recovery and reuse over seven cycles with negligible activity loss. Furthermore, the biological potential of the biogenic nanocomposite was assessed in vitro . 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays revealed significant, dose-dependent antiproliferative activity against Michigan cancer foundation-7 (MCF-7) and M. D. Anderson - metastatic breast – 231 (MDA-MB-231) breast cancer cell lines, with IC50 values of 198 µg/mL and 206 µg/mL, respectively. Notably, the material exhibited selectivity toward cancer cells, displaying nominal toxicity against normal cells. Additionally, the nanocomposite displayed substantial antioxidant capacity, yielding a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging IC50 of 192 µg/mL. These findings suggest that the CNT/Fe 3 O 4 /Pd nanocomposite holds promise as a dual-functional agent for both catalytic and therapeutic applications.
Hao et al. (Sat,) studied this question.