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July 13, 2026Polymer Reviews

Scaffold Mediated Delivery of Kartogenin for Replenishing Cartilage Defects: A Scoping Review on Recent Trends and Future Frontiers

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Authors

SVSurya VenkateshVIVaishnavi IyerBNBaiju G. Nair

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Overview

Scoping review highlights KGN delivery strategies for cartilage repair in osteoarthritis, suggesting new avenues for treatment.

Key Points

  • This review aims to explore recent advancements in the delivery of kartogenin (KGN) for cartilage regeneration, particularly in osteoarthritis.
  • Overview of various biomaterials and fabrication strategies used to functionalize KGN.
  • Emphasis on techniques like hydrogels, 3D bioprinting, electrospinning, and scaffold engineering.
  • Discussion of synthesis, structure, function, and applications of KGN-functionalized biomaterials.
  • KGN's chondrogenic and chondroprotective properties are enhanced when combined with appropriate biomaterials.
  • Functionalization strategies significantly improve the bioavailability and effectiveness of KGN in cartilage repair.
  • Identified limitations and future prospects highlight the potential for emerging technologies in cartilage regeneration.

Cite This Study

Venkatesh et al. (2026) studied this question.

synapsesocial.com/papers/6a5482a4475c38bf615a5c8chttps://doi.org/10.1080/15583724.2026.2701189
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