Neodymium–Ytterbium Pyrenates as High Reproducibility NIR Luminescent Thermometers for High-Temperature and Intracellular Sensing

Luminescent thermometry in the near-infrared (NIR) range remains a critical challenge for both high-temperature environments and live-cell applications. While reproducibility remains a crucial challenge, particularly for high-temperature applications. Here we report a series of lanthanide pyrenates (Yb,Nd)(pyr) 3 that demonstrate unprecedented reproducibility during thermal cycling up to 300 °C, with ratiometric temperature sensitivities reaching 8% K –1 . The complexes form stable nanoparticles exhibiting high emission intensities, low cytotoxicity, and temperature sensitivity (1.5% K –1 ) in the physiological range.