Key result
Heterozygous familial hypercholesterolaemia was associated with a substantial excess mortality from coronary heart disease (SMR 386; 95% CI 210-639), which was highest at age 20-39.
Why the study?
Does heterozygous familial hypercholesterolaemia increase the risk of fatal coronary heart disease and all-cause mortality compared to the general population?
Population
526 patients aged 20-74 with heterozygous familial hypercholesterolaemia from eleven hospital outpatient…
Design
Cohort
Follow-up
2234 person years during 1980-9
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May prompt earlier intervention in young adults with heterozygous FH; leaves open effects of modern therapies on this excess risk.
Cohort (n=526)
Yes
Does heterozygous familial hypercholesterolaemia increase the risk of fatal coronary heart disease and all-cause mortality compared to the general population?
Effect estimate: SMR 386 (95% CI 210-639)
Heterozygous familial hypercholesterolaemia is associated with a massive (nearly 100-fold) increased risk of fatal coronary heart disease in young adults aged 20-39 compared to the general population.
A 1991 study conducted a cohort in Heterozygous familial hypercholesterolaemia (n=526). Heterozygous familial hypercholesterolaemia vs. Standard population (all adults in England and Wales) was evaluated on Mortality from coronary heart disease (SMR 386, 95% CI 210-639). Heterozygous familial hypercholesterolaemia was associated with a substantial excess mortality from coronary heart disease (SMR 386; 95% CI 210-639), which was highest at age 20-39.
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