Key result
The G38S variant of the KCNE1 gene was not significantly associated with the QT interval in a population of 3,966 central European Caucasians.
Why the study?
Is the G38S variant of the KCNE1 gene associated with QT interval prolongation in a central European Caucasian population?
Observational (n=3,966)
Is the G38S variant of the KCNE1 gene associated with QT interval prolongation in a central European Caucasian population?
The G38S variant of the KCNE1 gene does not appear to have a strong modifying effect on the QT interval in central European Caucasians, failing to replicate previous family-based findings.
No QT association for G38S in central European Caucasians; leaves open ethnic-specific or conditional effects.
AIMS: The QT interval in the general population is a complex trait with 30-50% heritability. QT prolongation is associated with an increased risk of sudden death. A recent family-based study found an association between QT interval and the common non-synonymous Glycin 38 Serine variant (G38S, rs1805127) of the KCNE1 gene coding for the minK-potassium channel subunit. We intended to replicate this finding in a large population sample of central European Caucasian ancestry as part of our ongoing search for genetic variants predisposing to arrhythmias. METHODS AND RESULTS: We studied 3966 unrelated individuals from the KORA S4 population-based study without atrial fibrillation, pacemaker implant, or pregnancy. Individuals were genotyped by MALDI-TOF mass spectrometry. We did not detect any significant association between the genotypes of the G38S variant and the QT interval in the entire population or in any gender. CONCLUSION: Unlike the common Lysine 897 Threonine variant of KCNH2 (K897T, rs1805123) the G38S variant of KCNE1 does not appear to have a strong modifying effect on QT interval. However, we cannot rule out an effect of G38S on QT in other ethnic groups, under exercise or medications or on the risk for arrhythmias and sudden death.
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Akyol et al. (2007) conducted an observational in QT interval (n=3,966). G38S variant (rs1805127) of the KCNE1 gene vs. Other genotypes was evaluated on QT interval. The G38S variant of the KCNE1 gene was not significantly associated with the QT interval in a population of 3,966 central European Caucasians.
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