Global and regional coronary flow reserve derived by dynamic SPECT progressively decreased across worsening summed stress score categories, and identified reduced flow in older patients with normal MPI.
Observational (n=90)
Does dynamic SPECT-derived coronary flow reserve correlate with summed stress scores on conventional MPI in patients undergoing stress testing?
Dynamic SPECT-derived coronary flow reserve correlates with conventional MPI summed stress scores and can identify abnormal flow in older patients with otherwise normal conventional scans, potentially refining cardiac risk stratification.
a Background: Technological advancement in the recent years has enabled the application of single photon emission tomography (SPECT) to evaluate myocardial blood flow (MBF). This method offers increased sensitivity in the assessment of coronary health, quantifiable through non-invasive imaging beyond the more conventional methods such as with myocardial perfusion imaging (MPI). b Aims: To correlate MBF, derived by dynamic SPECT, both global and by coronary territories to the summed stress scores (SSS) on conventional MPI. c Methods: Images obtained from dipyridamole-gated SPECT MPI stress and rest studies performed on recruited subjects were examined. We calculated the global and regional coronary flow reserve (CFR) via a standard software package, taken as the ratio of stress MBF to rest MBF, using CFR 50%). We observed a progressive reduction in global and regional CFR across the normal SSS category to that of severely abnormal (SSS >13). Reduced global CFR with correspondent lower CFR across the regional arteries were detected in scans within normal limits of MPI scans in subjects who were older (69 ± 7 vs. 62 ± 9 years, p = 0.034). Decreasing CFR was significantly associated with increasing age across the regional arteries. e Conclusion: In our study we depict the global and regional MBF values obtained via SPECT MPI in correlation to the respective SSS categories. Our data proposes that dynamic SPECT has a part in refining cardiac risk stratification, particularly in the older adult population, who are at greater risk.
Chng et al. (Mon,) conducted a observational in Suspected coronary artery disease (n=90). Dynamic SPECT derived myocardial blood flow (MBF) and coronary flow reserve (CFR) vs. Conventional MPI summed stress scores (SSS) was evaluated on Correlation of global and regional coronary flow reserve (CFR) to summed stress scores (SSS). Global and regional coronary flow reserve derived by dynamic SPECT progressively decreased across worsening summed stress score categories, and identified reduced flow in older patients with normal MPI.