Brain-specific ORP6 deficiency in mice disrupts systemic lipid metabolism and impairs hippocampal-dependent learning and memory.

Key Points

• The research aims to investigate the effects of brain-specific ORP6 deficiency on lipid metabolism and cognitive functions in mice.
• Used Morris water maze and contextual fear conditioning to assess learning and memory
• Monitored lipid metabolism and cholesterol levels in mice with ORP6 deficiency
• Mice with ORP6 deficiency showed elevated levels of amyloid beta oligomers
• Impaired performance in Morris water maze and contextual fear conditioning tasks
• Demonstrated disruption in lipid homeostasis affecting cognitive function