Key result
P-selectin-targeted microbubbles double ultrasound signal in inflamed tissue compared to control microbubbles.
Why the study?
Does ultrasound imaging with microbubbles targeted to P-selectin improve the assessment of tissue inflammation in murine models of inflammation and ischemia-reperfusion injury?
Does ultrasound imaging with microbubbles targeted to P-selectin improve the assessment of tissue inflammation in murine models of inflammation and ischemia-reperfusion injury?
Absolute Event Rate: 12% vs 6%
p-value: p=<0.05
No takes yet. Share an insight, caveat, or question.
Microbubbles targeted to P-selectin produce strong signal enhancement on ultrasound imaging of inflamed tissue, suggesting a potential noninvasive method to assess inflammation and tissue injury.
Lindner et al. (2001) studied Inflammation and renal tissue injury. Phospholipid microbubbles targeted to P-selectin (MB(p)) vs. Control microbubbles without antibody (MB) or with isotype control antibody (MB(iso)) was evaluated on Ultrasound signal from microbubbles retained in inflamed tissue (p=<0.05). P-selectin-targeted microbubbles produced significantly higher ultrasound signal in inflamed renal tissue compared to isotype control microbubbles (12±2 U vs 6±3 U, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: