Key result
Circulating TMAO strongly correlates with CIMT and predicts cardiometabolic risk across BMI categories.
Why the study?
Obesity is a major contributor to cardiometabolic risks, including subclinical atherosclerosis and insulin resistance, prompting investigation into the roles of TMAO and resistin as obesity predictors and their associations with CIMT and metabolic parameters.
Cross-Sectional (n=60)
Effect estimate: r=0.674 for CIMT; AUC 0.880 for cardiometabolic risk
p-value: p=<0.001
TMAO and resistin levels are significantly associated with subclinical atherosclerosis and metabolic parameters, highlighting their potential utility in risk stratification for obesity-related cardiometabolic risks.
TMAO and resistin associations with obesity and CIMT are hypothesis-generating; leaves open predictive utility pending larger prospective studies.
Background: obesity is a major contributor to cardiometabolic risks, including subclinical atherosclerosis and insulin resistance. This study investigates the roles of Trimethylamine N-oxide (TMAO) and resistin as obesity predictors, examining their associations with carotid intima-media thickness (CIMT) and metabolic parameters; Methods: sixty adults (18–71 years), spanning normal weight to obesity, were assessed for body mass index (BMI), waist-to-hip ratio (WHR), and waist circumference (WC). Body composition was measured using the TANITA BC-418 device, while subclinical atherosclerosis was evaluated via CIMT with the Aixplorer MACH 30 ultrasound system. Blood samples were analyzed for TMAO, resistin, and metabolic biomarkers; Results: TMAO, resistin, CIMT, fat mass, glucose, HbA1c, and lipid profiles significantly increased across BMI categories (p<0.001). TMAO correlated strongly with CIMT (r=0.674, p<0.001), indicating its role in subclinical atherosclerosis. Logistic regression identified TMAO (threshold 380; AUC=0.880, accuracy=91.7%) as a predictor of cardiometabolic risk. Resistin was associated with CIMT, WHR, and total cholesterol, inversely linked to LDL cholesterol (p=0.003). Less active participants exhibited higher TMAO (p=0.001) and resistin (p=0.02). Family histories of obesity and diabetes correlated with elevated TMAO, while resistin linked to shorter sleep duration and diabetes history, highlighting their importance in obesity-related cardiometabolic risks; Conclusions: TMAO is closely associated with abdominal fat, insulin resistance, and subclinical atherosclerosis, while resistin relates to lipid profiles and aging. Together, they provide a nuanced predictive model for obesity-related cardiometabolic risks, reinforcing their value in risk stratification and targeted management.
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Pescari et al. (2025) conducted a cross-sectional in Obesity and cardiometabolic risk (n=60). Circulating TMAO and resistin levels was evaluated on Carotid intima-media thickness (CIMT) and cardiometabolic risk (r=0.674 for CIMT; AUC 0.880 for cardiometabolic risk, p=<0.001). Circulating TMAO strongly correlated with carotid intima-media thickness (r=0.674, p<0.001) and accurately predicted cardiometabolic risk (AUC=0.880) across BMI categories.
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