Key result
Isometric handgrip training for 8 weeks did not significantly improve brachial artery flow-mediated dilation compared to the non-exercised control limb in normotensive individuals (P=0.22).
Why the study?
Does isometric handgrip training improve brachial artery flow-mediated dilation in normotensive individuals?
Population
11 normotensive individuals
Comparison
Four 2-min unilateral isometric handgrip… vs Non-exercising limb (internal control)
Design
Other
Follow-up
8 weeks
Authors
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Does not support endothelial improvement with isometric handgrip training; leaves open alternative mechanisms for blood pressure effects in normotensives.
Does isometric handgrip training improve brachial artery flow-mediated dilation in normotensive individuals?
Absolute Event Rate: 0.029% vs 0.024%
p-value: p=0.22
Isometric handgrip training does not improve systemic endothelial function (measured by flow-mediated dilation) in normotensive individuals, suggesting other mechanisms are responsible for its blood pressure-lowering effects.
McGowan et al. (2007) studied Normal blood pressure (n=11). Isometric handgrip training vs. Non-exercising limb was evaluated on Brachial artery flow-mediated dilation (BA FMD) normalized to peak shear rate (p=0.22). Isometric handgrip training for 8 weeks did not significantly improve brachial artery flow-mediated dilation compared to the non-exercised control limb in normotensive individuals (P=0.22).
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