What question did this study set out to answer?

The research aims to determine the influence of oestradiol on TLR-dependent immune responses in women.

July 15, 2026CellsOpen Access

Is Oestradiol a Key Player in the Sex Differences in Innate Immunity Through Toll-like Receptor Activation?

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial investigates the effect of oestradiol on TLR-dependent immune responses in women, indicating genetic factors play a larger role.

The research aims to determine the influence of oestradiol on TLR-dependent immune responses in women.
Studied 16 women undergoing controlled ovarian hyperstimulation for in vitro fertilization.
Collected whole blood samples before treatment, during stimulation, and at ovulation triggering.
Assessed TLR expression, intracellular signaling pathways, and cytokine production in response to TLR ligands.
Oestradiol levels increased significantly from 48.1 to 1819.5 pg/mL (p < 0.001).
Minimal impact on TLR2/4 and CD99 expression, signaling, or cytokine release observed.
Only IL-6 and IL-10 showed significant increase in response to TLR2/6 stimulation, with IL-6 positively associated with oestradiol variation.

Popotas et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial investigates the effect of oestradiol on TLR-dependent immune responses in women, indicating genetic factors play a larger role.