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The study aims to synthesize 3-aroyl-2H-thiopyran-2-carboxylic acids and analyze their derivatives.

Synthesis of 3-Aroyl-2H-thiopyran-2-carboxylic Acids and Their Derivatives

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Synthesis of 3-aroyl-2H-thiopyran-2-carboxylic acids through acid-catalyzed reactions, suggesting efficient pathways for chemical development.

The study aims to synthesize 3-aroyl-2H-thiopyran-2-carboxylic acids and analyze their derivatives.
Utilized acid-catalyzed reactions of 3-aminoenthiones with tert-butyl β-aroylacrylates.
Cleaved the tert-butyl protective group using CF3COOH to produce carboxylic acids.
Reacted resulting compounds with hydrazine to obtain thiopyrano derivatives.
Successfully synthesized 3-aroyl-2H-thiopyran-2-carboxylic acids.
Generated 4H-thiopyrano[2,3-d]pyridazin-8(7H)-ones as derivatives.

Карпов et al. (2026) studied this question.

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Synthesis of 3-aroyl-2H-thiopyran-2-carboxylic acids through acid-catalyzed reactions, suggesting efficient pathways for chemical development.