PER977 reduced whole-blood clotting time significantly more rapidly than in controls among healthy persons who had received a single dose of edoxaban.
Does PER977 reduce whole-blood clotting time in healthy persons who received a single dose of edoxaban?
PER977 significantly accelerates the reversal of edoxaban-induced anticoagulation as measured by whole-blood clotting time.
Among 80 healthy persons who had received a single dose of edoxaban, the whole-blood clotting time was reduced significantly more rapidly in those who received the novel small molecule PER977 than in controls who were not given PER977.
Ansell et al. (2014) studied this question. PER977 reduced whole-blood clotting time significantly more rapidly than in controls among healthy persons who had received a single dose of edoxaban.