Key result
Diagnosis of silent coronary ischemia with selective revascularization reduced 2-year all-cause death compared to standard care in patients with CLTI (8.1% vs 20.0%; HR 0.38; 95% CI 0.18-0.84; P=0.016).
Why the study?
To determine whether diagnosing silent coronary ischemia before limb salvage surgery with selective postoperative coronary revascularization reduces adverse cardiac events and improves survival in CLTI compared with standard care.
Does the diagnosis of silent coronary ischemia with selective postoperative coronary revascularization reduce adverse cardiac events and improve survival in patients with critical limb-threatening ischemia compared with standard care?
Cohort (n=231)
Does the diagnosis of silent coronary ischemia with selective postoperative coronary revascularization reduce adverse cardiac events and improve survival in patients with critical limb-threatening ischemia compared with standard care?
Hazard Ratio: 0.38 (95% CI 0.18–0.84)
Absolute Event Rate: 8.1% vs 20%
p-value: p=.016
Supports silent ischemia screening in CLTI; leaves open routine adoption pending randomized confirmation.
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Krieviņš et al. (2021) conducted a cohort in Critical limb-threatening ischemia (n=231). Diagnosis of silent coronary ischemia with selective postoperative coronary revascularization vs. Standard care was evaluated on All-cause death (HR 0.38, 95% CI 0.18-0.84, p=.016). Diagnosis of silent coronary ischemia with selective revascularization reduced 2-year all-cause death compared to standard care in patients with CLTI (8.1% vs 20.0%; HR 0.38; 95% CI 0.18-0.84; P=0.016).
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